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KMID : 1137020080190020129
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Journal of Gynecologic Oncology
2008 Volume.19 No. 2 p.129 ~ p.134
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Original Article : The efficacy of concurrent cisplatin and 5-flurouracil chemotherapy and radiation therapy for Locally advanced cancer of the uterine cervix
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Choi Il-Jung
Cha Moon-Seok
Park Eunku-Seul
Han Myoung-Seok
Choi Young-Min
Je Goo-Hwa
Kim Hyun-Ho
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Abstract
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Objectives: To evaluate the efficacy of concurrent chemoradiation (CCRT) using 5-flurouracil (5-FU) and cisplatin for locally advanced cervical cancer.
Methods: We reviewed the medical records of 57 patients with locally advanced cervical cancer (stage IIB-IVA and bulky IB2-IIA tumor) who underwent the CCRT at Dong-A University Hospital from January 1997 to June 2007. The
CCRT consisted of 5-FU, cisplatin and pelvic radiation. Every three weeks, 75 mg/m2 cisplatin was administered on
the first day of each cycle and 5-FU was infused at the dose of 1,000 mg/m2/d from the second day to the fifth day of
each cycle. Radiation was administered to the pelvis at a daily dose of 1.8 Gy for five days per week until a medium
accumulated dose reached to 50.4 Gy. If necessary, the radiation field was extended to include paraaortic lymph nodes.
Consolidation chemotherapy was performed using 5-FU and cisplatin.
Results: Fifty-seven patients were enrolled and the median follow-up duration was 53 months (range 7-120 months). The overall response rate was 91.5% (74% complete response and 17.5% partial response). The 5-year overall survival and 3-year progression free survival rates were 69.4% and 74.9%, respectively. During the follow-up period (median 23 months, range 7-60 months), fourteen patients were diagnosed as recurrent disease.
Conclusion: CCRT with 5-FU and cisplatin which is the primary treatment for patients with locally advanced cervical
cancer was effective and well tolerated.
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KEYWORD
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Concurrent chemoradiation, CCRT, Locally advanced cervical cancer, Bulky cervical mass, Cisplatin, 5-fluorouracil
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